A more efficient, radiation-free alternative to systematic chest x-ray for the detection of embolized seeds to the lung

Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1052-6. doi: 10.1016/j.ijrobp.2009.09.012. Epub 2010 Mar 6.

Abstract

Purpose: To evaluate the efficacy of a seed-migration detector and to compare its performance to fluoroscopy and postoperative chest radiographs.

Methods and materials: A gamma scintillation survey meter was converted to a seed-migration detector by adding a shield on the probe detection window. The detector response to three (125)I seed activities was characterized for different source-to-detector distances in water. The detector was used to perform a chest evaluation on 737 patients at their first postoperative visit. When the detector showed positive activity, seed migration was confirmed by taking a chest radiograph and by looking at the region with fluoroscopy.

Results: One hundred and three patients (14.0%) presented at least one embolized seed. This accounts for 123 of the 39,887 seeds. Eighty-seven, 12, and 4 patients had respectively one, two, and three seed embolization. Compared with the seed-migration detector, detection based on fluoroscopy would have led to 13 false-negative detections (of 103, or 12.6%), and the radiograph would have resulted in 31 or 30.1%. More important, standard chest X-ray would have required a survey and extra radiation dose to lung to 100% of the patients, rather than the 14% who required it.

Conclusions: The usual recommendation to perform chest radiographs at the first follow-up visit to scan lungs for embolized seeds should be revised because of the high false-negative rate. Scintillator-based gamma counter detector provides superior detection sensitivity and should be adopted as a standard of practice. Chest X-ray could be limited to documenting cases of positive migration.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brachytherapy / adverse effects*
  • Brachytherapy / instrumentation
  • Calibration
  • False Negative Reactions
  • Fluoroscopy
  • Foreign-Body Migration / complications
  • Foreign-Body Migration / diagnostic imaging*
  • Gamma Cameras
  • Humans
  • Iodine Radioisotopes*
  • Lung*
  • Male
  • Prospective Studies
  • Prostatic Neoplasms / radiotherapy
  • Pulmonary Embolism / diagnostic imaging*
  • Pulmonary Embolism / etiology
  • Radionuclide Imaging

Substances

  • Iodine Radioisotopes