Abstract
Curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. For this reason, curcuminoids have been focused on as potential pharmaceuticals. Exogenous supplementation with various carboxylate precursors in genetically engineered Escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carboxylic Acids / metabolism
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Coumaric Acids / metabolism
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Curcumin / analogs & derivatives*
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Curcumin / isolation & purification
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Curcumin / metabolism
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Escherichia coli / genetics
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Escherichia coli / metabolism*
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Genetic Engineering
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Industrial Microbiology / methods*
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Organisms, Genetically Modified / genetics
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Organisms, Genetically Modified / metabolism
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Polyketide Synthases / metabolism
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Propionates
Substances
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Carboxylic Acids
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Coumaric Acids
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Propionates
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Polyketide Synthases
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p-coumaric acid
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Curcumin