Abstract
A phenotypic and genotypic analysis of Acinetobacter baumannii was conducted from 2003 to 2008 in Detroit, MI. The incidence of A. baumannii increased from 1.7 to 3.7/1,000 patient days during the study period. Susceptibility to ampicillin-sulbactam and imipenem decreased from approximately 90% to approximately 40%. Genotyping revealed polyclonality, suggesting either emergence of multiple resistant strains or spread of a common genetic element. The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrug-resistant pathogen.
MeSH terms
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Academic Medical Centers / statistics & numerical data
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Acinetobacter Infections / drug therapy*
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Ampicillin / therapeutic use
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Anti-Bacterial Agents / therapeutic use*
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Drug Resistance, Bacterial / genetics*
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Genotype
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Humans
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Imipenem / therapeutic use
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Michigan / epidemiology
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Phylogeny
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Prevalence
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Retrospective Studies
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Sulbactam / therapeutic use
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Urban Population / statistics & numerical data
Substances
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Anti-Bacterial Agents
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sultamicillin
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Imipenem
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Ampicillin
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Sulbactam