Temporal and spatial dynamics of rabies viruses in China and Southeast Asia

Virus Res. 2010 Jun;150(1-2):111-8. doi: 10.1016/j.virusres.2010.02.019. Epub 2010 Mar 7.

Abstract

Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514-1812) and the viruses circulating in Southeast Asia likely derived from China.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / genetics*
  • Asia, Southeastern / epidemiology
  • Cattle
  • China / epidemiology
  • Cluster Analysis
  • Dogs
  • Evolution, Molecular
  • Geography
  • Glycoproteins / genetics*
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics*
  • Rabies / epidemiology
  • Rabies / veterinary*
  • Rabies / virology
  • Rabies virus / classification*
  • Rabies virus / genetics*
  • Rabies virus / isolation & purification
  • Sequence Analysis, DNA
  • Sequence Homology
  • Swine
  • Time Factors
  • Viral Envelope Proteins / genetics*

Substances

  • Antigens, Viral
  • Glycoproteins
  • RNA, Viral
  • Viral Envelope Proteins
  • glycoprotein G, Rabies virus

Associated data

  • GENBANK/GU186379
  • GENBANK/GU186380
  • GENBANK/GU186381
  • GENBANK/GU186382
  • GENBANK/GU186383
  • GENBANK/GU186384
  • GENBANK/GU186385
  • GENBANK/GU186386
  • GENBANK/GU186387
  • GENBANK/GU186388
  • GENBANK/GU186389
  • GENBANK/GU186390
  • GENBANK/GU186391
  • GENBANK/GU186392
  • GENBANK/GU186393
  • GENBANK/GU186394
  • GENBANK/GU186395
  • GENBANK/GU186396
  • GENBANK/GU186397
  • GENBANK/GU186398
  • GENBANK/GU186399
  • GENBANK/GU186400
  • GENBANK/GU186401
  • GENBANK/GU186402
  • GENBANK/GU186403
  • GENBANK/GU186404
  • GENBANK/GU186405
  • GENBANK/GU186406
  • GENBANK/GU186407
  • GENBANK/GU186408
  • GENBANK/GU186409
  • GENBANK/GU186410
  • GENBANK/GU186411