Successful treatment of resistant antiglomerular basement membrane antibody positivity with mycophenolic acid

Intern Med. 2010;49(6):577-80. doi: 10.2169/internalmedicine.49.2321. Epub 2010 Mar 15.

Abstract

Anti-glomerular basement membrane (GBM) antibody disease may progress to end-stage renal failure, requiring either dialysis or renal transplantation. In patients with end-stage renal disease (ESRD) due to anti-GBM-ab disease, the recurrence rate after transplantation is as high as 50% (2) and delaying renal transplantation until circulating anti-GBM antibody levels have been undetectable for at least 12 months reduces the recurrence rate to 5-15%. We report a case of ESRD due to renal limited anti-GBM disease with circulating anti-GBM-ab resistant to standard treatment approach who achieved undetectable anti-GBM-ab with mycophenolic acid.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoantibodies / blood*
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / drug therapy*
  • Autoimmune Diseases / immunology
  • Biopsy
  • Female
  • Glomerulonephritis / complications
  • Glomerulonephritis / drug therapy*
  • Glomerulonephritis / immunology
  • Humans
  • Kidney / pathology
  • Kidney Failure, Chronic / etiology
  • Mycophenolic Acid / therapeutic use*
  • Treatment Outcome

Substances

  • Autoantibodies
  • antiglomerular basement membrane antibody
  • Mycophenolic Acid