Chromatin: the final frontier in splicing regulation?

Dev Cell. 2010 Mar 16;18(3):336-8. doi: 10.1016/j.devcel.2010.03.002.

Abstract

Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.

Publication types

  • Comment

MeSH terms

  • Alternative Splicing
  • Chromatin / genetics*
  • Chromatin / metabolism*
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Mesenchymal Stem Cells / metabolism
  • Models, Biological
  • Polypyrimidine Tract-Binding Protein / metabolism
  • RNA Interference
  • RNA Precursors / genetics
  • RNA Precursors / metabolism
  • RNA Splicing / genetics*
  • RNA Splicing / physiology*
  • Receptor, Fibroblast Growth Factor, Type 2 / genetics

Substances

  • Chromatin
  • Histones
  • RNA Precursors
  • Polypyrimidine Tract-Binding Protein
  • FGFR2 protein, human
  • Receptor, Fibroblast Growth Factor, Type 2