Structure-based discovery of natural-product-like TNF-α inhibitors

Angew Chem Int Ed Engl. 2010 Apr 6;49(16):2860-4. doi: 10.1002/anie.200907360. Epub 2010 Mar 16.

Abstract

Small but effective: two natural-product-like inhibitors of tumor necrosis factor α (TNF-α; represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule, and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Drug Discovery
  • Humans
  • Models, Molecular
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Biological Products
  • Tumor Necrosis Factor-alpha