Abstract
Problem:
Does addition of enoxaparin to sildenafil and etanercept immunotherapy improve IVF outcome?
Methods:
Report of a striking case with 15 IVF failures.
Result:
When enoxaparin was added, the 16th IVF cycle generated a healthy male baby.
Conclusions:
Combination therapy that includes a heparin may allow successful IVF outcome and this issue merits further study.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticoagulants / therapeutic use*
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Cytotoxicity, Immunologic / drug effects
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Drug Therapy, Combination
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Endometriosis / drug therapy
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Endometriosis / immunology
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Enoxaparin / therapeutic use*
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Etanercept
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Female
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Fertilization in Vitro*
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Humans
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Immunoglobulin G / therapeutic use*
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Immunosuppressive Agents / therapeutic use
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Immunotherapy / methods*
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Killer Cells, Natural / drug effects
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Live Birth
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Middle Aged
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Piperazines / therapeutic use*
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Pregnancy
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Pregnancy Complications
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Purines / therapeutic use
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Receptors, Tumor Necrosis Factor / therapeutic use*
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Sildenafil Citrate
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Sulfones / therapeutic use*
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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Anticoagulants
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Enoxaparin
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Immunoglobulin G
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Immunosuppressive Agents
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Piperazines
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Purines
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Receptors, Tumor Necrosis Factor
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Sulfones
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Tumor Necrosis Factor-alpha
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Sildenafil Citrate
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Etanercept