Abstract
The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / genetics*
-
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology*
-
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / microbiology*
-
Autoantibodies / immunology
-
Autoantigens / immunology
-
Bacterial Infections / complications
-
Bacterial Infections / immunology*
-
Cross Reactions
-
Genetic Predisposition to Disease
-
Genetic Variation*
-
Humans
-
Lysosomal-Associated Membrane Protein 2 / immunology
-
Molecular Mimicry
Substances
-
Autoantibodies
-
Autoantigens
-
Lysosomal-Associated Membrane Protein 2