[Locally recurrent prostate cancer following radiation therapy: radical salvage prostatectomy]

Urologe A. 2010 Jun;49(6):734-40. doi: 10.1007/s00120-009-2064-7.
[Article in German]

Abstract

Radical salvage prostatectomy represents a secondary local treatment with curative intent in patients with organ-confined prostate cancer (PC) recurrences following radiation therapy. Preoperative risk factors predicting organ-confined disease are initial low dose rate (LDR) brachytherapy, preoperative Gleason biopsy score<or=6, <or=50% biopsy cores involved with cancer, and a prostate-specific antigen (PSA) doubling time>12 months. Metastatic disease should be ruled out preoperatively by skeletal scintigraphy, abdominal computed tomography or magnetic resonance imaging, and/or choline-PET/CT. Functionality of the lower urinary tract needs to be preoperatively evaluated by urethrocystoscopy and urodynamics. With appropriate patient selection, oncological control can be achieved in 80% of patients. A continence rate of 83%-96% depending on the type of previous radiation therapy is achievable.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Biomarkers, Tumor / blood
  • Biopsy
  • Brachytherapy
  • Disease-Free Survival
  • Follow-Up Studies
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery*
  • Neoplasm Staging
  • Positron-Emission Tomography
  • Postoperative Complications / etiology
  • Prostate / pathology
  • Prostate-Specific Antigen / blood
  • Prostatectomy*
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / radiotherapy*
  • Prostatic Neoplasms / surgery*
  • Radiotherapy Dosage
  • Salvage Therapy / methods*
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • Prostate-Specific Antigen