Abstract
In vitro investigations on the combination effect of radiation and carboplatin (CBDCA) in three human cell lines (HeLa, MRI-186 Caski) show purely additive effects. Study of the molecular lesions gave considerable differences in the time course of repair of radiation induced DNA-double strand-breaks and of formation of DNA-crosslinks by carboplatin. However, sequential treatment with intervals of up to +/- 24 hours resulted also in an additive effect. In the experimental systems studied, a true radiosensitization was not demonstrated.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adenocarcinoma / drug therapy
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Adenocarcinoma / radiotherapy
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Carboplatin / pharmacology*
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / radiotherapy
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Cell Line
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Cobalt Radioisotopes / pharmacology*
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Combined Modality Therapy
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DNA Repair / drug effects
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DNA, Neoplasm / drug effects
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DNA, Neoplasm / radiation effects
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Female
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HeLa Cells
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Humans
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Radiation-Sensitizing Agents
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Tumor Cells, Cultured / drug effects*
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Tumor Cells, Cultured / radiation effects*
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Uterine Cervical Neoplasms / drug therapy
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Uterine Cervical Neoplasms / radiotherapy
Substances
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Cobalt Radioisotopes
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DNA, Neoplasm
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Radiation-Sensitizing Agents
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Carboplatin