High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system

Rapid Commun Mass Spectrom. 2010 Apr 30;24(8):1207-10. doi: 10.1002/rcm.4461.
No abstract available

Publication types

  • Letter

MeSH terms

  • Automation, Laboratory / methods
  • Chromatography, Liquid / methods
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / chemistry
  • Drug Discovery / methods*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • High-Throughput Screening Assays / methods*
  • Linear Models
  • Mass Spectrometry / methods*
  • Midazolam / analogs & derivatives
  • Midazolam / chemistry

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System
  • 1-hydroxymethylmidazolam
  • Midazolam