Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania

Rémy Dureau; Florence Robert-Gangneux; Jean-Pierre Gangneux; Caroline Nugier-Chauvin; Laurent Legentil; Richard Daniellou; Vincent Ferrières

doi:10.1016/j.carres.2010.02.020

Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania

Carbohydr Res. 2010 Jul 2;345(10):1299-305. doi: 10.1016/j.carres.2010.02.020. Epub 2010 Feb 24.

Authors

Rémy Dureau¹, Florence Robert-Gangneux, Jean-Pierre Gangneux, Caroline Nugier-Chauvin, Laurent Legentil, Richard Daniellou, Vincent Ferrières

Affiliation

¹ Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France.

PMID: 20303072
DOI: 10.1016/j.carres.2010.02.020

Abstract

The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / chemistry
Antiprotozoal Agents / pharmacology*
Leishmania donovani / drug effects*
Leishmania donovani / growth & development*
Pentoses / chemical synthesis*
Pentoses / chemistry
Pentoses / pharmacology*
Uridine Diphosphate / chemistry*

Substances

Antiprotozoal Agents
Pentoses
Uridine Diphosphate