A novel D-glucose derivative radiolabeled with technetium-99m: synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor

André Luís Branco de Barros; Valbert Nascimento Cardoso; Luciene das Graças Mota; Elaine Amaral Leite; Mônica Cristina de Oliveira; Ricardo José Alves

doi:10.1016/j.bmcl.2010.03.003

A novel D-glucose derivative radiolabeled with technetium-99m: synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2478-80. doi: 10.1016/j.bmcl.2010.03.003. Epub 2010 Mar 3.

Authors

André Luís Branco de Barros¹, Valbert Nascimento Cardoso, Luciene das Graças Mota, Elaine Amaral Leite, Mônica Cristina de Oliveira, Ricardo José Alves

Affiliation

¹ Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

PMID: 20303753
DOI: 10.1016/j.bmcl.2010.03.003

Abstract

A d-glucose-MAG(3) derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Thus, d-glucose-MAG(3) could be considered as agent for tumor diagnosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinoma, Ehrlich Tumor / metabolism*
Carcinoma, Ehrlich Tumor / pathology
Glucose / chemical synthesis
Glucose / chemistry
Glucose / pharmacokinetics*
Mice
Organotechnetium Compounds / chemistry*
Tissue Distribution

Substances

Organotechnetium Compounds
Glucose