Direct chemical glycosylation with pentenyl- and thioglycoside donors of N-acetylglucosamine

Carbohydr Res. 2010 May 7;345(7):872-9. doi: 10.1016/j.carres.2010.02.013. Epub 2010 Feb 19.

Abstract

The use of pentenyl and thiophenyl glycosides of N-acetylglucosamine (GlcNAc) as glycosyl donors for the direct preparation of O-glycosides of GlcNAc promoted by N-iodosuccinimide (NIS) and metal triflates in dichloromethane has been investigated. Both glycosyl acceptors 1-octanol and (-)-menthol resulted in good glycosylation yields for both types of donors with pentenyl glycosides being somewhat superior in terms of yield. Carbohydrate-based acceptors were reacted with a benzylated GlcNAc-pentenyl donor but only provided disaccharides in poor to moderate yields. The results show that a variety of metal triflates are capable of acting as an activator for both NIS and the intermediate oxazoline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylglucosamine / chemistry*
  • Glycosides / chemistry*
  • Glycosylation
  • Oxazoles / chemistry
  • Succinimides / chemistry

Substances

  • Glycosides
  • Oxazoles
  • Succinimides
  • succinimide
  • Acetylglucosamine