[Prevalence of anti-Leishmania spp antibodies in dogs from Garanhuns, in the middle scrub zone (Agreste) of Pernambuco]

Rev Soc Bras Med Trop. 2010 Jan-Feb;43(1):41-5. doi: 10.1590/s0037-86822010000100010.
[Article in Portuguese]

Abstract

Introduction: Considering the unknown situation regarding canine visceral leishmaniasis in Garanhuns, this study had the aim of investigating occurrences of anti-Leishmania spp antibodies in domesticated and partially domesticated dogs, and the possible risk factors involved.

Methods: In the first phase of the study, 256 blood samples were collected from dogs and subjected to the indirect fluorescent antibody test (IFAT) reaction at a dilution of 1:40. Additionally, 23 IFAT-positive samples were tested using an immunochromatographic dipstick test. In the second phase, new blood samples were collected from 18 dogs that were IFAT-positive in the first phase. These animals were retested using IFAT (1:40 and 1:80) and, additionally, by means of the polymerase chain reaction to investigate the Leishmania infantum DNA. Furthermore, 16 of these samples were retested using the immunochromatographic dipstick test.

Results: In the first phase of the study, 16% of the samples were IFAT-positive (1:40) and only three (13%) were positive in the immunochromatographic dipstick test. In the second phase, 12 samples were IFAT-positive at the dilution of 1:40, and seven were also positive at 1:80. None of the samples were positive in the polymerase chain reaction testing or in the immunochromatographic dipstick test. Clinical signs suggestive of visceral leishmaniasis were observed in 4.9% of the IFAT-positive dogs. There were no statistical differences in relation to age, sex or clinical status of the dogs, but there was a difference in relation to place of origin.

Conclusions: The domesticated and partially domesticated dogs living in Garanhuns present anti-Leishmania spp antibodies, but are mostly asymptomatic.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / blood*
  • Brazil / epidemiology
  • DNA, Protozoan / analysis
  • Dog Diseases / diagnosis
  • Dog Diseases / epidemiology*
  • Dogs
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Immunoassay
  • Leishmania donovani* / genetics
  • Leishmania donovani* / immunology
  • Leishmaniasis, Visceral / diagnosis
  • Leishmaniasis, Visceral / epidemiology
  • Leishmaniasis, Visceral / veterinary*
  • Male
  • Polymerase Chain Reaction
  • Prevalence
  • Sensitivity and Specificity
  • Seroepidemiologic Studies

Substances

  • Antibodies, Protozoan
  • DNA, Protozoan