Abstract
The susceptibilities of pneumococci recently collected (up to June 2009) in Spain (500 isolates nonsusceptible to oral penicillin and 150 susceptible isolates) from serotypes not included in the conjugate vaccine were determined. Most nonsusceptible isolates (53.6%) belonged to serotype 19A. Susceptibility rates in serotype 19A penicillin-intermediate (n = 201)/penicillin-resistant (n = 67) isolates were <33%/< or =6.0% (erythromycin and oral cephalosporins with defined breakpoints), 85.1%/11.9% (amoxicillin), and 96.0%/52.2% (cefotaxime), respectively. Low susceptibility to common oral beta-lactams was also found in serotypes 11A (95.5% susceptibility to cefotaxime and erythromycin) and 35B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Anti-Bacterial Agents / administration & dosage*
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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In Vitro Techniques
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Microbial Sensitivity Tests
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Penicillin Resistance
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Penicillins / administration & dosage*
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Pneumococcal Infections / drug therapy*
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / microbiology*
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Pneumococcal Infections / prevention & control
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Pneumococcal Vaccines / pharmacology
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Serotyping
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Spain / epidemiology
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Species Specificity
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / isolation & purification
Substances
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Anti-Bacterial Agents
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Heptavalent Pneumococcal Conjugate Vaccine
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Penicillins
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Pneumococcal Vaccines