Abstract
Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases ( 2 years). These findings support a role of OPN in AD pathogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alzheimer Disease / cerebrospinal fluid*
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Alzheimer Disease / epidemiology*
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Alzheimer Disease / pathology
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Brain / diagnostic imaging
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Brain / pathology
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Cognition Disorders / diagnosis
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Cognition Disorders / epidemiology*
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Disease Progression
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Magnetic Resonance Imaging
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Male
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Microglia / diagnostic imaging
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Microglia / pathology
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Nerve Degeneration / cerebrospinal fluid
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Nerve Degeneration / epidemiology
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Nerve Degeneration / pathology
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Neuropsychological Tests
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Osteopontin / cerebrospinal fluid*
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Positron-Emission Tomography
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Severity of Illness Index
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tau Proteins / cerebrospinal fluid