Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

Angew Chem Int Ed Engl. 2010 Apr 12;49(17):3081-5. doi: 10.1002/anie.200904902.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism
  • Amino Acid Sequence
  • Amyloid / chemistry
  • Amyloid / metabolism*
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / metabolism*
  • Binding Sites
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Islet Amyloid Polypeptide
  • Molecular Sequence Data
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism
  • Protein Binding

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Islet Amyloid Polypeptide
  • Peptide Fragments
  • amyloid beta-protein (1-40)