Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

ChemMedChem. 2010 Jun 7;5(6):837-40. doi: 10.1002/cmdc.201000045.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / toxicity
  • Binding Sites
  • Cell Line
  • Computer Simulation
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • HIV Reverse Transcriptase / metabolism
  • HIV-1 / drug effects
  • Humans
  • Protein Structure, Tertiary
  • Pyrimidines / chemical synthesis
  • Pyrimidines / chemistry*
  • Pyrimidines / toxicity
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • Pyrimidines
  • reverse transcriptase, Human immunodeficiency virus 1
  • HIV Reverse Transcriptase