Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Eur Child Adolesc Psychiatry. 2010 Aug;19(8):647-58. doi: 10.1007/s00787-010-0102-z. Epub 2010 Mar 25.

Abstract

Inasmuch as the newly established DSM-oriented CBCL/6-18 scales are to be increasingly employed to assess clinical/high-risk populations, it becomes important to explore their aetiology both within the normal- and the extreme range of variation in general population samples and to compare the results obtained in different age groups. We investigated by the Quantitative Maximum Likelihood, the De Fries-Fulker, and the Ordinal Maximum Likelihood methods the genetic and environmental influences upon the five DSM-oriented CBCL/6-18 scales in 796 twins aged 8-17 years belonging to the general population-based Italian Twin Registry. When children were analysed together regardless of age, most best-fitting solutions yielded genetic and non-shared environmental factors as the sole influences for DSM-oriented CBCL/6-18 behaviours, both for the normal and the extreme variations. When analyses were conducted separately for two age groups, shared environmental influences emerged consistently for Affective and Anxiety Problems in children aged 8-11. Oppositional-Defiant, Attention Deficit/Hyperactivity, and Conduct Problems appeared-with few exceptions-influenced only by genetic and non-shared environmental factors in both age groups, according to all three computational approaches. The De Fries-Fulker method appeared to be more sensitive in detecting shared environmental effects. Analysing the same set of data with different analytic approaches leads to better-balanced views on the aetiology of psychopathological behaviours in the developmental years.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adolescent
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / genetics
  • Anxiety Disorders / psychology
  • Attention Deficit Disorder with Hyperactivity / diagnosis
  • Attention Deficit Disorder with Hyperactivity / genetics
  • Attention Deficit Disorder with Hyperactivity / psychology
  • Attention Deficit and Disruptive Behavior Disorders / diagnosis
  • Attention Deficit and Disruptive Behavior Disorders / genetics
  • Attention Deficit and Disruptive Behavior Disorders / psychology
  • Child
  • Child Behavior Disorders / diagnosis
  • Child Behavior Disorders / genetics*
  • Child Behavior Disorders / psychology*
  • Conduct Disorder / diagnosis
  • Conduct Disorder / genetics
  • Conduct Disorder / psychology
  • Diagnostic and Statistical Manual of Mental Disorders*
  • Diseases in Twins / diagnosis
  • Diseases in Twins / genetics*
  • Diseases in Twins / psychology
  • Female
  • Genotype*
  • Humans
  • Likelihood Functions
  • Male
  • Mood Disorders / diagnosis
  • Mood Disorders / genetics
  • Mood Disorders / psychology
  • Personality Assessment / statistics & numerical data*
  • Phenotype
  • Psychometrics / statistics & numerical data
  • Registries
  • Reproducibility of Results
  • Risk Factors
  • Social Environment*