Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides

Ghilsoo Nam; Yang Soo Kim; Kyung Il Choi

doi:10.1016/j.bmcl.2010.01.153

Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2671-4. doi: 10.1016/j.bmcl.2010.01.153. Epub 2010 Mar 1.

Authors

Ghilsoo Nam¹, Yang Soo Kim, Kyung Il Choi

Affiliation

¹ Neuro-medicines Research center, Life & Health Division, Korea Institute of Science and Technology (KIST), Seoungbuk-gu, Seoul 136-791, Republic of Korea. [email protected]

PMID: 20338761
DOI: 10.1016/j.bmcl.2010.01.153

Abstract

A novel series of 9-O-arylpropenyloxime ketolide was synthesized and evaluated for their antibacterial activity. This series of ketolide exhibited potent activity against clinically isolated gram-positive strains including Staphylococcus pneumoniae and Straptococcus Pyogenes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Ketolides / chemical synthesis*
Ketolides / chemistry
Ketolides / pharmacology*
Microbial Sensitivity Tests
Streptococcus pneumoniae / drug effects
Streptococcus pyogenes / drug effects

Substances

Anti-Bacterial Agents
Ketolides