Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5. doi: 10.1016/j.bmcl.2010.03.015. Epub 2010 Mar 7.

Abstract

The design and enzyme activities of a novel class of imidazo[2,1-b]thiazoles is presented.

MeSH terms

  • ErbB Receptors / antagonists & inhibitors*
  • Models, Molecular
  • Protein Kinase Inhibitors / chemistry
  • Protein Kinase Inhibitors / pharmacology*
  • Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*

Substances

  • Protein Kinase Inhibitors
  • Thiazoles
  • ErbB Receptors
  • Receptor Protein-Tyrosine Kinases