Abstract
We describe 66 ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates recovered from colonized and infected children. The ParC S79A substitution was frequent and associated with the emm6/sequence type 382 (emm6/ST382) lineage. The ParC D83G substitution was detected in two isolates (emm5/ST99 and emm28/ST52 lineages). One isolate (emm89/ST101) had no quinolone resistance-determining region codon substitutions or other resistance mechanisms. Five of 66 isolates were levofloxacin resistant. Although fluoroquinolones are not used in children, they may be putative disseminators of fluoroquinolone-nonsusceptible strains in the community.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Anti-Bacterial Agents / pharmacology*
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Antigens, Bacterial / genetics
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Typing Techniques
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Carrier Proteins / genetics
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Child
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Ciprofloxacin / pharmacology*
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Drug Resistance, Bacterial / genetics
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Humans
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Molecular Epidemiology
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Norfloxacin / pharmacology
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Point Mutation
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Portugal / epidemiology
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Streptococcal Infections / drug therapy*
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Streptococcal Infections / epidemiology
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Streptococcal Infections / microbiology*
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Streptococcus pyogenes / classification
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / genetics
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Streptococcus pyogenes / isolation & purification*
Substances
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Anti-Bacterial Agents
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Carrier Proteins
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streptococcal M protein
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Ciprofloxacin
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Norfloxacin