Abstract
A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both (64)Cu and (99m)Tc. Conjugation to a bombesin derivative was achieved using standard solid phase synthetic methodologies and the (64)Cu-labeled conjugate was shown to have good tumour uptake in mice with xenografted PC-3 tumours.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacokinetics
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Chelating Agents / chemistry*
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacokinetics
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Copper / chemistry*
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Electron Spin Resonance Spectroscopy
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Isotope Labeling
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Ligands
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Mice
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Mice, Nude
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Peptides / chemistry*
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Temperature
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Thiosemicarbazones / chemistry*
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Tissue Distribution
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Transplantation, Heterologous
Substances
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Antineoplastic Agents
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Chelating Agents
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Coordination Complexes
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Ligands
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Peptides
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Thiosemicarbazones
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Copper