Objective: To investigate the clinical characteristics and therapy of laryngeal neuroendocrine carcinoma (LNEC).
Method: Ten cases of LNEC treated in our department were retrospectively analyzed.
Result: Eight out of 10 cases were were atypical carcinoid: 1 case treated as supraglottic horizontal partial laryngectomy died 22 months after operation; 1 case was lost; the other 6 cases were followed up for more than 2 years. Two cases were small cell type, one received supra-cricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP), neck dissection, and radiotherapy, but died after 14 months; the other was receiving radiotherapy.
Conclusion: LNEC is a rare malignant tumor and the diagnosis relies on clinical characteristics, histopathological and immunohistochemistry examination. The different types of LNEC should give different treatment protocols.