Abstract
This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alnus* / chemistry
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Animals
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology*
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Antiviral Agents / toxicity
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Cell Survival / drug effects
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Cells, Cultured
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Chick Embryo
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Dose-Response Relationship, Drug
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Fibroblasts / drug effects
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Fibroblasts / pathology
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Influenza A Virus, H9N2 Subtype / drug effects*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Pentacyclic Triterpenes / pharmacology
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Plant Bark
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Sitosterols / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Steroids / chemistry
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Steroids / isolation & purification
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Steroids / pharmacology*
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Steroids / toxicity
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Triterpenes / toxicity
Substances
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Antiviral Agents
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Pentacyclic Triterpenes
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Sitosterols
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Steroids
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Triterpenes
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gamma-sitosterol
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betulin
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lupeol