Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Ana Belén Galván; Mar Mallo; Leonor Arenillas; Marta Salido; Blanca Espinet; Carmen Pedro; Lourdes Florensa; Sergi Serrano; Francesc Solé

doi:10.1016/j.leukres.2010.03.022

Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Leuk Res. 2010 Sep;34(9):1242-5. doi: 10.1016/j.leukres.2010.03.022. Epub 2010 Apr 1.

Authors

Ana Belén Galván¹, Mar Mallo, Leonor Arenillas, Marta Salido, Blanca Espinet, Carmen Pedro, Lourdes Florensa, Sergi Serrano, Francesc Solé

Affiliation

¹ Laboratori de Citogenètica Molecular. Servei de Patologia, Parc Salut Mar. GRETNHE, IMIM-Hospital del Mar, Barcelona, Spain.

PMID: 20362335
DOI: 10.1016/j.leukres.2010.03.022

Abstract

Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 5*
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Monosomy*
Myelodysplastic Syndromes / genetics*