Highly effective treatment with tacrolimus ointment in an adolescent with oral graft-versus-host disease

T Bauters; V Bordon; V Van de Velde; S Van Lancker; H Robays; Y Benoit; G Laureys

doi:10.1007/s11096-010-9386-9

Highly effective treatment with tacrolimus ointment in an adolescent with oral graft-versus-host disease

Pharm World Sci. 2010 Jun;32(3):350-2. doi: 10.1007/s11096-010-9386-9. Epub 2010 Apr 4.

Authors

T Bauters¹, V Bordon, V Van de Velde, S Van Lancker, H Robays, Y Benoit, G Laureys

Affiliation

¹ Department of Pharmacy, Ghent University Hospital, -1 K12, De Pintelaan 185, 9000, Ghent, Belgium. [email protected]

PMID: 20364437
DOI: 10.1007/s11096-010-9386-9

Abstract

Case: We report a case of acute oral graft-versus-host disease in an adolescent, which was successfully treated with tacrolimus 0.1% ointment.

Conclusion: Although tacrolimus ointment is not licensed for the indication of oral GvHD, this case report provides preliminary evidence for a potential effectiveness of using tacrolimus in case of failure when GvHD is resistant.

Publication types

Case Reports

MeSH terms

Adolescent
Graft vs Host Disease / diagnosis*
Graft vs Host Disease / drug therapy*
Humans
Male
Mouth Mucosa / pathology*
Ointments
Tacrolimus / administration & dosage*
Tongue / pathology
Tongue Diseases / diagnosis
Tongue Diseases / drug therapy*
Tongue Diseases / pathology
Treatment Outcome

Substances

Ointments
Tacrolimus