Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor

Angew Chem Int Ed Engl. 2010 May 25;49(23):3960-3. doi: 10.1002/anie.200907153.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Cell Line
  • Databases, Protein
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / pharmacology
  • Proteasome Endopeptidase Complex / chemistry*
  • Proteasome Endopeptidase Complex / metabolism
  • Protein Binding
  • Proteomics*

Substances

  • Anti-Inflammatory Agents
  • Enzyme Inhibitors
  • petrosaspongiolide m
  • Oleanolic Acid
  • Proteasome Endopeptidase Complex
  • ATP dependent 26S protease