Paradoxical reaction to treatment in 2 patients with severe acute paracoccidioidomycosis: a previously unreported complication and its management with corticosteroids

Clin Infect Dis. 2010 May 15;50(10):e56-8. doi: 10.1086/652290.

Abstract

Paradoxical reactions have never been described in patients with paracoccidioidomycosis or other deep endemic mycoses out of the context of human immunodeficiency virus infection. We describe 2 patients with an acute form of paracoccidioidomycosis who presented with a worsening of their clinical manifestations while on appropriate antifungal treatment. These manifestations were severe and required adjunct corticosteroid therapy.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use*
  • Antifungal Agents / adverse effects*
  • Antifungal Agents / therapeutic use*
  • Child
  • Histocytochemistry
  • Humans
  • Immunohistochemistry
  • Immunologic Factors / therapeutic use*
  • Lymph Nodes / pathology
  • Lymphomatoid Granulomatosis / chemically induced*
  • Lymphomatoid Granulomatosis / pathology
  • Male
  • Microscopy
  • Neck / pathology
  • Paracoccidioidomycosis / complications*
  • Paracoccidioidomycosis / drug therapy*
  • Skin / pathology

Substances

  • Adrenal Cortex Hormones
  • Antifungal Agents
  • Immunologic Factors