Abstract
Mouse fibroblasts are reprogrammed to functional neurons by expression of a few transcription factors.
MeSH terms
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Action Potentials
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Animals
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Biomarkers / analysis
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Cell Line
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Cell Lineage
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Cell Transdifferentiation
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Cells, Cultured
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Embryo, Mammalian / cytology
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Fibroblasts / cytology*
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Mice
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Models, Biological*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Neurons / cytology*
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Neurons / metabolism
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Neurons / physiology*
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Oligodendrocyte Transcription Factor 2
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POU Domain Factors / genetics
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POU Domain Factors / metabolism
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Regenerative Medicine
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Synapses / metabolism
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Tail / cytology
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Time Factors
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Ascl1 protein, mouse
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Basic Helix-Loop-Helix Transcription Factors
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Biomarkers
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Nerve Tissue Proteins
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Olig2 protein, mouse
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Oligodendrocyte Transcription Factor 2
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POU Domain Factors
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Transcription Factors
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Zic1 protein, mouse
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Pou3f2 protein, mouse