Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams

Helena Cerić; Marija Sindler-Kulyk; Miće Kovacević; Mihaela Perić; Andreja Zivković

doi:10.1016/j.bmc.2010.03.045

Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams

Bioorg Med Chem. 2010 May 1;18(9):3053-8. doi: 10.1016/j.bmc.2010.03.045. Epub 2010 Mar 27.

Authors

Helena Cerić¹, Marija Sindler-Kulyk, Miće Kovacević, Mihaela Perić, Andreja Zivković

Affiliation

¹ PLIVA Croatia Ltd, TAPI R&D, Chemical R&D, Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia.

PMID: 20382539
DOI: 10.1016/j.bmc.2010.03.045

Abstract

A simple and efficient procedure for the stereoselective synthesis of new azetidinone-isothiazolidinones has been developed. New compounds were tested in vitro on a panel of Gram-positive and Gram-negative bacterial pathogens, some of them showing weak antibacterial activity.

Publication types

Comparative Study

MeSH terms

Amoxicillin / pharmacology
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Azetidines / chemistry*
Bacteria / drug effects*
Microbial Sensitivity Tests
Molecular Structure
Monobactams / chemical synthesis*
Monobactams / chemistry
Monobactams / pharmacology*
Stereoisomerism
Thiazolidines / chemistry*

Substances

2-azetidinone
Anti-Bacterial Agents
Azetidines
Monobactams
Thiazolidines
Amoxicillin