[Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Oct;23(5):364-6.
[Article in Chinese]

Abstract

Objective: To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.

Methods: 26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.

Results: The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.

Conclusion: HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Hepatitis B virus / physiology
  • Hepatitis B, Chronic / genetics*
  • Hepatitis B, Chronic / pathology
  • Hepatitis B, Chronic / virology
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Severity of Illness Index
  • Young Adult

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains