Time course of expression of "early" genes during long-term posttetanic potentiation in rat hippocampal CA1 field

O O Sokolova; M B Shtark; P D Lisachev; V O Pustyl'nyak; I V Pan

doi:10.1007/s10517-010-0726-5

Time course of expression of "early" genes during long-term posttetanic potentiation in rat hippocampal CA1 field

Bull Exp Biol Med. 2009 Sep;148(3):416-8. doi: 10.1007/s10517-010-0726-5.

[Article in English, Russian]

Authors

O O Sokolova¹, M B Shtark, P D Lisachev, V O Pustyl'nyak, I V Pan

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia.

PMID: 20396702
DOI: 10.1007/s10517-010-0726-5

Abstract

The expression of egr-1, junB, c-jun, and c-fos genes in rat hippocampal CA1 field was studied by the real-time PCR 30, 60, and 120 min after induction of long-term posttetanic potentiation. The content of egr-1, junB, and c-jun mRNA gradually increased and doubled 120 min after tetanization. The increase in c-jun mRNA level lagged behind the increment of egr-1 and junB. The level of c-fos mRNA increased 30 min after tetanization, returned to the initial level by min 60, and again increased 120 min after induction of long-term posttetanic potentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Early Growth Response Protein 1 / genetics
Hippocampus / metabolism*
Long-Term Potentiation / genetics
Long-Term Potentiation / physiology*
Polymerase Chain Reaction
Proto-Oncogene Proteins c-fos / genetics
Proto-Oncogene Proteins c-jun / genetics
RNA, Messenger / genetics
RNA, Messenger / metabolism
Rats

Substances

Early Growth Response Protein 1
Egr1 protein, rat
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
RNA, Messenger