Temperamentsxgenes in bipolar I and bipolar II disorder patients

Ching-I Lin; Sheng-Yu Lee; Yun-Hsuan Chang; Jo Yung-Wei Wu; Yi-Syuan Wu; Pei-Lin Wu; Hui-Chun Chen; Shiou-Lan Chen; I Hui Lee; Tzung Lieh Yeh; Yen Kuang Yang; Huei-Chen Ko; Ru-Band Lu

doi:10.1016/j.psychres.2010.03.005

Temperamentsxgenes in bipolar I and bipolar II disorder patients

Psychiatry Res. 2010 May 30;177(3):364-6. doi: 10.1016/j.psychres.2010.03.005. Epub 2010 Apr 18.

Authors

Ching-I Lin¹, Sheng-Yu Lee, Yun-Hsuan Chang, Jo Yung-Wei Wu, Yi-Syuan Wu, Pei-Lin Wu, Hui-Chun Chen, Shiou-Lan Chen, I Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Huei-Chen Ko, Ru-Band Lu

Affiliation

¹ Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.

PMID: 20399505
DOI: 10.1016/j.psychres.2010.03.005

Abstract

We found the main effects of harm avoidance temperament in predicting bipolar I and II, but the interaction between novelty seeking and Ser9Gly polymorphisms of dopamine D3 receptor gene was demonstrated in bipolar-I patients only. This study provided evidence that differences existed between BP-I and BPII in gene and temperament interactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bipolar Disorder* / classification
Bipolar Disorder* / genetics
Bipolar Disorder* / physiopathology
DNA Mutational Analysis
Exploratory Behavior / physiology
Female
Genotype
Glycine / genetics
Humans
Male
Personality Inventory
Polymorphism, Genetic / genetics*
Psychiatric Status Rating Scales
Receptors, Dopamine D3 / genetics*
Regression Analysis
Serine / genetics
Taiwan / ethnology
Temperament / physiology*

Substances

Receptors, Dopamine D3
Serine
Glycine