Abstract
A panel of stable [Au(R-C--N--C)(N-heterocyclic carbene)](+) complexes displays prominent in vitro anticancer properties; [Au(C--N--C)(IMe)]CF(3)SO(3) (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents / toxicity
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Carcinoma, Hepatocellular / drug therapy
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Computer Simulation
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Coordination Complexes / chemistry*
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Coordination Complexes / therapeutic use
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Coordination Complexes / toxicity
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DNA Topoisomerases, Type I / metabolism
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Gold / chemistry*
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Hep G2 Cells
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Heterocyclic Compounds / chemistry*
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Humans
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Ligands
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Liver Neoplasms / drug therapy
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Methane / analogs & derivatives*
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Methane / chemistry
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Mice
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Mice, Nude
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Topoisomerase I Inhibitors*
Substances
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Antineoplastic Agents
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Coordination Complexes
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Heterocyclic Compounds
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Ligands
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Topoisomerase I Inhibitors
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carbene
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Gold
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DNA Topoisomerases, Type I
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Methane