Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements

Int J Gynecol Pathol. 2010 May;29(3):228-33. doi: 10.1097/PGP.0b013e3181c04007.

Abstract

A 73-year-old woman was found to have a 22 cm unilateral multilocular mucinous cystic tumor of the ovary. Microscopic examination showed a routine appearance of the epithelial component, which ranged from benign to borderline to low-grade carcinoma. The stromal component was unusual because of a striking cellular theca cell component in the stroma, which, in turn, merged with a component of adult granulosa cell tumor. The "parent" neoplasm in this case and 3 other similar cases in the literature appears to be the mucinous neoplasm, in contrast with the other example of mucinous neoplasia associated with sex cord neoplasia, the Sertoli-Leydig cell tumor with heterologous elements, in which the "parent" neoplasm is likely the Sertoli-Leydig cell tumor.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adenocarcinoma, Mucinous / pathology*
  • Adenocarcinoma, Mucinous / surgery
  • Aged
  • Female
  • Granulosa Cell Tumor / pathology*
  • Granulosa Cell Tumor / surgery
  • Histocytochemistry
  • Humans
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Sertoli-Leydig Cell Tumor / pathology*
  • Thecoma / pathology*
  • Thecoma / surgery