Abstract
In this work we studied the in vitro toxicity of +/- 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-dichlorophenoxy]quinoline (DN3-27-1) against stationary phase promastigotes Leishmania (L.) mexicana. Our results indicate that this drug induces an important reduction in parasite growth and killing compared to the reference drug N-methyl meglumine (Glucantime). DN3-27-1 was not toxic to Hela cells cultured in vitro. This is the first report describing the promising potential of DN3-27-1 in treatment of L. (L.) mexicana infections.
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry*
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Antiprotozoal Agents / toxicity*
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Cell Survival / drug effects
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HeLa Cells
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Humans
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Leishmania mexicana / drug effects*
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Leishmania mexicana / growth & development
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Leishmania mexicana / ultrastructure
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Lethal Dose 50
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Meglumine / pharmacology
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Meglumine Antimoniate
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Motor Activity / drug effects
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Organometallic Compounds / pharmacology
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Quinolines / chemistry*
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Quinolines / toxicity
Substances
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8-((4-amino-1-methylbutyl)amino)-6-methoxy-4-methyl-5-(3,4-dichlorophenoxy)quinoline
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Antiprotozoal Agents
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Organometallic Compounds
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Quinolines
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Meglumine
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Meglumine Antimoniate