Abstract
Carbon nanotubes (CNTs) have a great potential for applications in medicine. However, their biocompatibility and toxicity cause a great concern. Due to the large surface area of CNTs, chemical modification can dramatically alter their physiochemical properties and hence biological activity. Using a combinatorial chemistry approach, we report the synthesis of an 80-member surface-modified nanotube library. Based upon screening of this library with respect to protein-binding capacity, cytotoxicity, and immune response, we were able to select highly biocompatible nanotubes with reduced protein-binding cytotoxicity and immune response.
MeSH terms
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Animals
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Biocompatible Materials / toxicity*
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Carbonic Anhydrases / chemistry
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Carbonic Anhydrases / immunology
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Cattle
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Cells, Cultured
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Chymotrypsin / chemistry
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Chymotrypsin / immunology
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Combinatorial Chemistry Techniques / methods*
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Hemoglobins / chemistry
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Hemoglobins / immunology
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Humans
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Materials Testing
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Nanotubes, Carbon / chemistry
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Nanotubes, Carbon / toxicity*
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Serum Albumin, Bovine / chemistry
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Serum Albumin, Bovine / immunology
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Surface Properties
Substances
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Biocompatible Materials
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Hemoglobins
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Nanotubes, Carbon
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Serum Albumin, Bovine
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Chymotrypsin
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Carbonic Anhydrases