Abstract
The macrolactonization of peptide thioester to yield cyclic depsipeptides was developed using imidazole as a catalyst. This strategy was applied to the synthesis of kahalalide B and its analogues.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Catalysis
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Depsipeptides / chemical synthesis*
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Depsipeptides / chemistry
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Imidazoles / chemistry*
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Lactones / chemistry*
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Molecular Structure
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Sulfhydryl Compounds / chemical synthesis*
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Sulfhydryl Compounds / chemistry
Substances
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Depsipeptides
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Imidazoles
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Lactones
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Peptides, Cyclic
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Sulfhydryl Compounds
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kahalalide B
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imidazole