The purpose of this article is to review recent developments in the role of CT colonography with an emphasis on colorectal cancer screening. An introduction to the concept and method of CT colonography is given as well as a summary of the data on performance of CT colonography. Furthermore, details on side effects, efficacy and cost-effectiveness and the possible role of extracolonic findings are provided. The impact CTC could have on colonoscopy and other possible indications of the method are also mentioned.