Access to original vinylic chlorides in the quinazoline series via a monoelectronic transfer reaction approach

Martine Maillard-Boyer; Caroline Castera-Ducros; Pierre Verhaeghe; France Sifredi; Pascal Rathelot; Patrice Vanelle

doi:10.3390/molecules15042719

Access to original vinylic chlorides in the quinazoline series via a monoelectronic transfer reaction approach

Molecules. 2010 Apr 13;15(4):2719-29. doi: 10.3390/molecules15042719.

Authors

Martine Maillard-Boyer¹, Caroline Castera-Ducros, Pierre Verhaeghe, France Sifredi, Pascal Rathelot, Patrice Vanelle

Affiliation

¹ Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d'Aix-Marseille I, II et III - UMR CNRS 6264, Laboratoire Chimie Provence, 27 Boulevard Jean Moulin, Marseille cedex 05, France. [email protected]

Abstract

A series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive S(RN)1 / E(RC)1 radical strategy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / chemical synthesis
Antimalarials / chemistry*
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Protein Kinase Inhibitors / chemical synthesis
Protein Kinase Inhibitors / chemistry*
Quinazolines / chemical synthesis
Quinazolines / chemistry*
Vinyl Chloride / chemistry*

Substances

Antimalarials
Antineoplastic Agents
Protein Kinase Inhibitors
Quinazolines
Vinyl Chloride