Enhancement of NAD-linked isocitrate dehydrogenase activity in rat liver by clofibrate feeding

Biochem Pharmacol. 1991 Jun 1;41(11):1773-5. doi: 10.1016/0006-2952(91)90183-6.

Abstract

After feeding rats for 3 weeks with clofibrate specific activities of the liver mitochondrial enzymes glycerol-3-phosphate dehydrogenase (G3PDH) and NAD-linked isocitrate dehydrogenase (NAD-ICDH) were found to be increased in a large particle fraction 6-fold and 1.6-fold, respectively, whereas the activity of NADP-linked isocitrate dehydrogenase (NADP-ICDH) remained unchanged. Possibly these effects contribute to the hypolipidemic action of clofibrate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Clofibrate / administration & dosage
  • Clofibrate / pharmacology*
  • Diet
  • Isocitrate Dehydrogenase / metabolism*
  • Liver / drug effects
  • Liver / enzymology*
  • Male
  • Mitochondria, Liver / enzymology
  • Organ Size / drug effects
  • Rats
  • Rats, Inbred Strains

Substances

  • Isocitrate Dehydrogenase
  • Clofibrate