Crohn's disease (CD) incidence is characterized by a wide variability in different countries. In our area it hasn't developed yet any epidemiologic study about this disease. We have reviewed fifty-four new cases diagnosed in Zaragoza University Clinical Hospital (Spain) during the period 1974-1988. The most striking facts were that the incidence of Crohn's Disease increased steadily during the 15-year period studied and the existence of a statistical association between smoking and CD. Other features were similar those previously described in the literature.