Abstract
Hepatitis E is a worldwide public health problem, especially in areas with poor sanitation. This study examines the potential hepatitis E virus (HEV) animal reservoirs and the current status of HEV infection among animals and humans in an endemic area of Xinjiang, China. One thousand five hundred twenty-one serum samples from 12 different animal species and 296 sera from humans were detected for anti-HEV with an in-house enzyme immunoassay, and partial HEV RNA was amplified with a reverse transcription-nested polymerase chain reaction (RT-nPCR). All these distinct animal species, except jerboa and hoptoad, were positive for anti-HEV. However, HEV RNA was only amplified from pigs and a sporadic hepatitis E case in humans. The human HEV strain (CHN-XJ-HE29) shared 100% nucleotide identity with the swine HEV strain (CHN-XJ-SW50), both of which were collected from the same district; this indicates the possibility of HEV transmission from swine to humans in an endemic area.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Animals, Domestic
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Anura
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Disease Reservoirs
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Fishes
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Genotype
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Hepatitis Antibodies / blood
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Hepatitis E / transmission
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Hepatitis E / veterinary*
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Hepatitis E / virology
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Hepatitis E virus / classification
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Hepatitis E virus / genetics
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Hepatitis E virus / immunology
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Hepatitis E virus / isolation & purification*
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Humans
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Male
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Molecular Sequence Data
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Phylogeny
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RNA, Viral / blood
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Rodentia
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Species Specificity
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Swine
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Swine Diseases / transmission*
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Swine Diseases / virology
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Zoonoses
Substances
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Hepatitis Antibodies
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RNA, Viral
Associated data
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GENBANK/FJ775165
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GENBANK/FJ775166
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GENBANK/FJ775167
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GENBANK/FJ775168
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GENBANK/FJ775169
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GENBANK/FJ775170
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GENBANK/FJ775171
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GENBANK/FJ775172
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GENBANK/FJ775173
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GENBANK/FJ775174
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GENBANK/FJ775175
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GENBANK/FJ775176
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GENBANK/FJ775177
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GENBANK/FJ775178
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GENBANK/GQ305997
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GENBANK/GQ305998
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GENBANK/GQ305999
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GENBANK/GQ306000
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GENBANK/GQ306001
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GENBANK/GQ306002
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GENBANK/GQ306003
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GENBANK/GQ306004