Effect of gastric bypass on vitamin D and secondary hyperparathyroidism

Obes Surg. 2010 Jul;20(7):949-52. doi: 10.1007/s11695-010-0178-z.

Abstract

Obesity as well as bariatric surgery may increase the risk for vitamin D deficiency. We retrospectively compared vitamin D levels in obese patients (n = 123) prior to bariatric surgery and 1 year postoperatively. We also evaluated parathyroid hormone levels (PTH) 1 year after surgery. A higher percentage of patients had baseline vitamin D deficiency (86%), defined as 25-hydroxy vitamin D <32 ng/mL, compared with the 1-year (post-surgical) levels, (70%; p < 0.001). Body mass index (BMI) inversely correlated with vitamin D deficiency at baseline (r = -0.3, p = 0.06) and at the postoperative follow-up (r = -0.2, p = 0.013). One third of the postoperative population had secondary hyperparathyroidism, defined by a serum PTH level >62 pg/mL; however, postoperative PTH and vitamin D levels were unrelated (r = -0.001, p = 0.994). Pre- and postoperative vitamin D levels were inversely correlated with BMI. Secondary hyperparathyroidism was observed in 33% of patients postoperatively; however, this did not correlate with vitamin D.

MeSH terms

  • Body Mass Index
  • Calcium / blood
  • Female
  • Follow-Up Studies
  • Gastric Bypass / adverse effects*
  • Humans
  • Hyperparathyroidism, Secondary / epidemiology
  • Hyperparathyroidism, Secondary / etiology*
  • Male
  • Obesity, Morbid / blood*
  • Obesity, Morbid / complications
  • Obesity, Morbid / surgery*
  • Parathyroid Hormone / blood
  • Postoperative Period
  • Retrospective Studies
  • Risk
  • Vitamin D / blood
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / etiology*
  • Weight Loss

Substances

  • Parathyroid Hormone
  • Vitamin D
  • Calcium