Abstract
Infliximab is a potent therapy for induction and maintenance of remission in Crohn's disease. Unfortunately, many patients lose response and/or develop allergic reactions caused by the chimeric antibody. By means of measuring the presence of antibodies against infliximab and the trough levels of the drug, it seems easier to predict whether patients will respond to intensified dose regimens or will rather benefit from a switch to alternative agents.
MeSH terms
-
Antibodies, Anti-Idiotypic / immunology
-
Antibodies, Monoclonal / administration & dosage*
-
Antibodies, Monoclonal / immunology
-
Crohn Disease / drug therapy*
-
Crohn Disease / immunology*
-
Drug Delivery Systems
-
Drug Resistance / immunology
-
Female
-
Humans
-
Infliximab
-
Male
-
Prognosis
-
Risk Assessment
-
Treatment Outcome
-
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
-
Tumor Necrosis Factor-alpha / immunology
Substances
-
Antibodies, Anti-Idiotypic
-
Antibodies, Monoclonal
-
Tumor Necrosis Factor-alpha
-
Infliximab