Pregnancy during TNFalpha antagonist therapy: beware the rifampin-oral contraceptive interaction. Report of two cases

Cécile Wibaux; Irina Andrei; Julien Paccou; Peggy Philippe; Emmanuel Biver; Bernard Duquesnoy; René Marc Flipo

doi:10.1016/j.jbspin.2010.02.001

Pregnancy during TNFalpha antagonist therapy: beware the rifampin-oral contraceptive interaction. Report of two cases

Joint Bone Spine. 2010 May;77(3):268-70. doi: 10.1016/j.jbspin.2010.02.001. Epub 2010 May 5.

Authors

Cécile Wibaux¹, Irina Andrei, Julien Paccou, Peggy Philippe, Emmanuel Biver, Bernard Duquesnoy, René Marc Flipo

Affiliation

¹ Service de rhumatologie, hôpital Roger-Salengro, CHRU de Lille, université de Lille-2, rue Emile-Laine, 59037 Lille cedex, France. [email protected]

PMID: 20447852
DOI: 10.1016/j.jbspin.2010.02.001

Abstract

We report two cases of pregnancy in patients taking TNFalpha antagonists for chronic inflammatory joint disease. A factor in both pregnancies was the use of rifampin concomitantly with a combined oral contraceptive. Both patients were taking rifampin and isoniazid for tuberculosis prophylaxis in compliance with French recommendations for patients with positive intradermal tuberculin tests who are scheduled to receive biotherapeutic agents.

Publication types

Case Reports

MeSH terms

Adult
Antirheumatic Agents / adverse effects*
Antitubercular Agents / adverse effects*
Contraceptives, Oral / adverse effects*
Drug Interactions
Female
Humans
Immunocompromised Host
Isoniazid / adverse effects
Pregnancy
Rifampin / adverse effects*
Spondylitis, Ankylosing / drug therapy*
Spondylitis, Ankylosing / immunology
Tuberculosis, Pulmonary / immunology
Tuberculosis, Pulmonary / prevention & control*
Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

Antirheumatic Agents
Antitubercular Agents
Contraceptives, Oral
Tumor Necrosis Factor-alpha
Isoniazid
Rifampin