Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate

Chem Commun (Camb). 2010 Apr 21;46(15):2632-4. doi: 10.1039/b927215c. Epub 2010 Feb 6.

Abstract

We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage*
  • Carrier Proteins / chemistry*
  • Carrier Proteins / metabolism
  • Dendrimers / chemical synthesis
  • Dendrimers / chemistry*
  • Doxorubicin / administration & dosage*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry
  • Folate Receptors, GPI-Anchored
  • Folic Acid / chemistry
  • Nanostructures / chemistry*
  • Photolysis
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / metabolism
  • Ultraviolet Rays*

Substances

  • Antibiotics, Antineoplastic
  • Carrier Proteins
  • Dendrimers
  • Drug Carriers
  • Folate Receptors, GPI-Anchored
  • PAMAM Starburst
  • Receptors, Cell Surface
  • Doxorubicin
  • Folic Acid